Bacterial MbtH-like Proteins Stimulate Nonribosomal Peptide Synthetase-Derived Secondary Metabolism in Filamentous Fungi
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Lincosamide Synthetase—A Unique Condensation System Combining Elements of Nonribosomal Peptide Synthetase and Mycothiol Metabolism
In the biosynthesis of lincosamide antibiotics lincomycin and celesticetin, the amino acid and amino sugar units are linked by an amide bond. The respective condensing enzyme lincosamide synthetase (LS) is expected to be an unusual system combining nonribosomal peptide synthetase (NRPS) components with so far unknown amino sugar related activities. The biosynthetic gene cluster of celesticetin ...
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Among the filamentous fungi the rate of the endogenous respiration, which often is a useful measure of endogenous metabolism, usually is high as compared to the total respiration in the presence of exogenous substrates. This feature is not limited to the fungi alone and may be found under certain conditions in bacteria (Dawes and Holms, 1958) and in animal tissues as well (Allen et al., 1955). ...
متن کاملNonribosomal peptide synthesis in Aspergillus fumigatus and other fungi.
In fungi, nonribosomal peptide synthetases (NRP synthetases) are large multi-functional enzymes containing adenylation, thiolation (or peptidyl carrier protein, PCP) and condensation domains. These enzymes are often encoded within gene clusters. Multiple NRP synthetase ORFs have also been identified in fungi (14 in Aspergillus fumigatus). LeaA, a methyltransferase, is involved in secondary meta...
متن کاملReview Nonribosomal peptide synthesis in Aspergillus fumigatus and other fungi
In fungi, nonribosomal peptide synthetases (NRP synthetases) are large multi-functional enzymes containing adenylation, thiolation (or peptidyl carrier protein, PCP) and condensation domains. These enzymes are often encoded within gene clusters. Multiple NRP synthetase ORFs have also been identified in fungi (14 in Aspergillus fumigatus). LeaA, a methyltransferase, is involved in secondary meta...
متن کاملThe crystal structure of BlmI as a model for nonribosomal peptide synthetase peptidyl carrier proteins.
Carrier proteins (CPs) play a critical role in the biosynthesis of various natural products, especially in nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) enzymology, where the CPs are referred to as peptidyl-carrier proteins (PCPs) or acyl-carrier proteins (ACPs), respectively. CPs can either be a domain in large multifunctional polypeptides or standalone proteins, termed ...
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ژورنال
عنوان ژورنال: ACS Synthetic Biology
سال: 2019
ISSN: 2161-5063,2161-5063
DOI: 10.1021/acssynbio.9b00106